Diagnosis and Prognosis of Occupational disorders based on Machine Learn- ing Techniques applied to Occupational Profiles

Work-related disorders have a global influence on people’s well-being and quality of life and are a financial burden for organizations because they reduce productivity, increase absenteeism, and promote early retirement. Work-related musculoskeletal disorders, in particular, represent a significant fraction of the total in all occupational contexts. In automotive and industrial settings where workers are exposed to work-related muscu- loskeletal disorders risk factors, occupational physicians are responsible for monitoring workers’ health protection profiles. Occupational technicians report in the Occupational Health Protection Profiles database to understand which exposure to occupational work- related musculoskeletal disorder risk factors should be ensured for a given worker. Occu- pational Health Protection Profiles databases describe the occupational physician states, and which exposure the physicians considers necessary to ensure the worker’s health protection in terms of their functional work ability. The application of Human-Centered explainable artificial intelligence can support the decision making to go from worker’s Functional Work Ability to explanations by integrating explainability into medical (re- striction) and supporting in two decision contexts: prognosis and diagnosis of individual, work related and organizational risk condition. Although previous machine learning ap- proaches provided good predictions, their application in an actual occupational setting is limited because their predictions are difficult to interpret and hence, not actionable. In this thesis, injured body parts in which the ability changed in a worker’s functional work ability status are targeted. On the one hand, artificial intelligence algorithms can help technical teams, occupational physicians, and ergonomists determine a worker’s workplace risk via the diagnosis and prognosis of body part(s) injuries; on the other hand, these approaches can help prevent work-related musculoskeletal disorders by identifying which processes are lacking in working condition improvement and which workplaces have a better match between the remaining functional work abilities. A sample of 2025 for the prognosis part (from the years of 2019 to 2020) and 7857 for the prognosis part of Occupational Health Protection Profiles based on Functional Work Ability textual re- ports in the Portuguese language in automotive industry factory. Machine learning-based Natural Language Processing methods were implemented to extract standardized infor- mation. The prognosis and diagnosis of Occupational Health Protection Profiles factors were developed in reliable Human-Centered explainable artificial intelligence system to promote a trustworthy Human-Centered explainable artificial intelligence system (enti- tled Industrial microErgo application). The most suitable regression models to predict the next medical appointment for the injured body regions were the models based on CatBoost regression, with R square and an RMSLE of 0.84 and 1.23 weeks, respectively. In parallel, CatBoost’s best regression model for most body parts is the prediction of the next injured body parts based on these two errors. This information can help tech- nical industrial teams understand potential risk factors for Occupational Health Protec- tion Profiles and identify warning signs of the early stages of musculoskeletal disorders.Os transtornos relacionados ao trabalho têm influência global no bem-estar e na quali- dade de vida das pessoas e são um ônus financeiro para as organizações, pois reduzem a produtividade, aumentam o absenteísmo e promovem a aposentadoria precoce. Os distúr- bios osteomusculares relacionados ao trabalho, em particular, representam uma fração significativa do total em todos os contextos ocupacionais. Em ambientes automotivos e industriais onde os trabalhadores estão expostos a fatores de risco de distúrbios osteomus- culares relacionados ao trabalho, os médicos do trabalho são responsáveis por monitorar os perfis de proteção à saúde dos trabalhadores. Os técnicos do trabalho reportam-se à base de dados dos Perfis de Proteção da Saúde Ocupacional para compreender quais os fatores de risco de exposição a perturbações músculo-esqueléticas relacionadas com o tra- balho que devem ser assegurados para um determinado trabalhador. As bases de dados de Perfis de Proteção à Saúde Ocupacional descrevem os estados do médico do trabalho e quais exposições os médicos consideram necessária para garantir a proteção da saúde do trabalhador em termos de sua capacidade funcional para o trabalho. A aplicação da inteligência artificial explicável centrada no ser humano pode apoiar a tomada de decisão para ir da capacidade funcional de trabalho do trabalhador às explicações, integrando a explicabilidade à médica (restrição) e apoiando em dois contextos de decisão: prognóstico e diagnóstico da condição de risco individual, relacionado ao trabalho e organizacional . Embora as abordagens anteriores de aprendizado de máquina tenham fornecido boas pre- visões, sua aplicação em um ambiente ocupacional real é limitada porque suas previsões são difíceis de interpretar e portanto, não acionável. Nesta tese, as partes do corpo lesiona- das nas quais a habilidade mudou no estado de capacidade funcional para o trabalho do trabalhador são visadas. Por um lado, os algoritmos de inteligência artificial podem aju- dar as equipes técnicas, médicos do trabalho e ergonomistas a determinar o risco no local de trabalho de um trabalhador por meio do diagnóstico e prognóstico de lesões em partes do corpo; por outro lado, essas abordagens podem ajudar a prevenir distúrbios muscu- loesqueléticos relacionados ao trabalho, identificando quais processos estão faltando na melhoria das condições de trabalho e quais locais de trabalho têm uma melhor correspon- dência entre as habilidades funcionais restantes do trabalho. Para esta tese, foi utilizada uma base de dados com Perfis de Proteção à Saúde Ocupacional, que se baseiam em relató- rios textuais de Aptidão para o Trabalho em língua portuguesa, de uma fábrica da indús- tria automóvel (Auto Europa). Uma amostra de 2025 ficheiros foi utilizada para a parte de prognóstico (de 2019 a 2020) e uma amostra de 7857 ficheiros foi utilizada para a parte de diagnóstico. . Aprendizado de máquina- métodos baseados em Processamento de Lingua- gem Natural foram implementados para extrair informações padronizadas. O prognóstico e diagnóstico dos fatores de Perfis de Proteção à Saúde Ocupacional foram desenvolvidos em um sistema confiável de inteligência artificial explicável centrado no ser humano (inti- tulado Industrial microErgo application). Os modelos de regressão mais adequados para prever a próxima consulta médica para as regiões do corpo lesionadas foram os modelos baseados na regressão CatBoost, com R quadrado e RMSLE de 0,84 e 1,23 semanas, res- pectivamente. Em paralelo, a previsão das próximas partes do corpo lesionadas com base nesses dois erros relatados pelo CatBoost como o melhor modelo de regressão para a mai- oria das partes do corpo. Essas informações podem ajudar as equipes técnicas industriais a entender os possíveis fatores de risco para os Perfis de Proteção à Saúde Ocupacio- nal e identificar sinais de alerta dos estágios iniciais de distúrbios musculoesqueléticos

Different protocols for analyzing behavior and adaptability in obstacle crossing in Parkinson's disease

Imbalance and tripping over obstacles as a result of altered gait in older adults, especially in patients with Parkinson's disease (PD), are one of the most common causes of falls. During obstacle crossing, patients with PD modify their behavior in order to decrease the mechanical demands and enhance dynamic stability. Various descriptions of dynamic traits of gait that have been collected over longer periods, probably better synthesize the underlying structure and pattern of fluctuations in gait and can be more sensitive markers of aging or early neurological dysfunction and increased risk of falls. This confirmation challenges the clinimetric of different protocols and paradigms used for gait analysis up till now, in particular when analyzing obstacle crossing. The authors here present a critical review of current knowledge concerning the interplay between the cognition and gait in aging and PD, emphasizing the differences in gait behavior and adaptability while walking over different and challenging obstacle paradigms, and the implications of obstacle negotiation as a predictor of falls. Some evidence concerning the effectiveness of future rehabilitation protocols on reviving obstacle crossing behavior by trial and error relearning, taking advantage of dual-task paradigms, physical exercise, and virtual reality have been put forward in this article.Supported by the projects NORTE-01–0145-FEDER-000026 (DeM-Deus Ex Machina) financed by the Regional Operational Program of the North (NORTE2020) PORTUGAL2020 and FEDER, and FP7 Marie Curie ITN Neural Engineering Transformative Technologies (NETT) projectinfo:eu-repo/semantics/publishedVersio

Automotive Occupational Health Protection Profiles in Prevention Musculoskeletal Symptoms

This work was partly supported by science and technology foundation (FCT), under projects OPERATOR (ref. 04/SI/2019) and PREVOCUPAI (DSAIPA/AI/0105/2019), and Ph.D. grants PD/BDE/142816/2018 and PD/BDE/142973/2018.In automotive and industrial settings, occupational physicians are responsible for monitoring workers' health protection profiles. Workers' Functional Work Ability (FWA) status is used to create Occupational Health Protection Profiles (OHPP). This is a novel longitudinal study in comparison with previous research that has predominantly relied on the causality and explainability of human-understandable models for industrial technical teams like ergonomists. The application of artificial intelligence can support the decision-making to go from a worker's Functional Work Ability to explanations by integrating explainability into medical (restriction) and support in contexts of individual, work-related, and organizational risk conditions. A sample of 7857 for the prognosis part of OHPP based on Functional Work Ability in the Portuguese language in the automotive industry was taken from 2019 to 2021. The most suitable regression models to predict the next medical appointment for the workers' body parts protection were the models based on CatBoost regression, with an RMSLE of 0.84 and 1.23 weeks (mean error), respectively. CatBoost algorithm is also used to predict the next body part severity of OHPP. This information can help our understanding of potential risk factors for OHPP and identify warning signs of the early stages of musculoskeletal symptoms and work-related absenteeism.publishersversionpublishe

Objective graphical clustering of spatiotemporal gait pattern in patients with Parkinsonism

The goal of this study was grouping patients with parkinsonism that share similar gait characteristics based on principal component analysis (PCA). Spatiotemporal gait data during self-selected walking were obtained from 15 patients with Vascular Parkinsonism, 15 patients with Idiopathic Parkinson's Disease and 15 Controls. PCA was used to reduce the dimensionality of 12 gait characteristics for the 45 subjects. Fuzzy C-mean cluster analysis was performed plotting the first two principal components, which accounted for 84.1% of the total variability. Results indicates that it is possible to quantitatively differentiate different gait types in patients with parkinsonism using PCA. Objective graphical classification of gait patterns could assist in clinical evaluation as well as aid treatment planning.POCI-01-0145-FEDER-006961National Funds through the FCT as part of project UID/EEA/50014/201

Occupational health knowledge discovery based on association rules applied to workers’ body parts protection: a case study in the automotive industry

Occupational Health Protection (OHP) is mandatory by law and can be accomplished by considering the participation of others besides occupational physicians. The data shared can originate knowledge that might influence other processes related to occupational risk prevention. In this study, we used Artificial Intelligence (AI) methods to extract patterns among records shared under these circumstances over two years in the automotive industry. Records featuring OHP data against physical working conditions were selected, and a database of 383 profiles was designed. As Occupational Health Protection profiles under study are associated with work functional ability reduction, the body part(s) (n = 14) where it occurred were identified. Association Rules (ARs) coupled with Natural Language Processing techniques were applied to find meaningful hidden relationships and to identify the occurrence of protection profiles being assigned to at least two body parts simultaneously. After filtering ARs using three metrics (support, confidence, and lift), 54 ARs were found. The distribution of simultaneous body parts is presented as being higher in Special projects (n = 5). The results can use in: (i) design a multi-site body parts functional work ability (loss) model; (ii) model the capacity of organizations to retain workers in their working settings and (iii) prevent work-related musculoskeletal symptoms.</p

A genetic algorithm approach to design job rotation schedules ensuring homogeneity and diversity of exposure in the automotive industry

Publisher Copyright: © 2022 The Author(s)Job rotation is a work organization strategy with increasing popularity, given its benefits for workers and companies, especially those working with manufacturing. This study proposes a formulation to help the team leader in an assembly line of the automotive industry to achieve job rotation schedules based on three major criteria: improve diversity, ensure homogeneity, and thus reduce exposure level. The formulation relied on a genetic algorithm, that took into consideration the biomechanical risk factors (EAWS), workers’ qualifications, and the organizational aspects of the assembly line. Moreover, the job rotation plan formulated by the genetic algorithm formulation was compared with the solution provided by the team leader in a real life-environment. The formulation proved to be a reliable solution to design job rotation plans for increasing diversity, decreasing exposure, and balancing homogeneity within workers, achieving better results in all of the outcomes when compared with the job rotation schedules created by the team leader. Additionally, this solution was less time-consuming for the team leader than a manual implementation. This study provides a much-needed solution to the job rotation issue in the manufacturing industry, with the genetic algorithm taking less time and showing better results than the job rotations created by the team leaders.publishersversionpublishe

Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism

Accepted ManuscriptThe literature on gait analysis in Vascular Parkinsonism (VaP), addressing issues such as variability, foot clearance patterns, and the effect of levodopa, is scarce. This study investigates whether spatiotemporal, foot clearance and stride-to-stride variability analysis can discriminate VaP, and responsiveness to levodopa. Fifteen healthy subjects, 15 Idiopathic Parkinson's Disease (IPD) patients and 15 VaP patients, were assessed in two phases: before (Off-state), and one hour after (On-state) the acute administration of a suprathreshold (1.5 times the usual) levodopa dose. Participants were asked to walk a 30-meter continuous course at a self-selected walking speed while wearing foot-worn inertial sensors. For each gait variable, mean, coefficient of variation (CV), and standard deviations SD1 and SD2 obtained by Poincaré analysis were calculated. General linear models (GLMs) were used to identify group differences. Patients were subject to neuropsychological evaluation (MoCA test) and Brain MRI. VaP patients presented lower mean stride velocity, stride length, lift-off and strike angle, and height of maximum toe (later swing) (p < .05), and higher %gait cycle in double support, with only the latter unresponsive to levodopa. VaP patients also presented higher CV, significantly reduced after levodopa. Yet, all VaP versus IPD differences lost significance when accounting for mean stride length as a covariate. In conclusion, VaP patients presented a unique gait with reduced degrees of foot clearance, probably correlated to vascular lesioning in dopaminergic/non-dopaminergic cortical and subcortical non-dopaminergic networks, still amenable to benefit from levodopa. The dependency of gait and foot clearance and variability deficits from stride length deserves future clarification.projects NORTE-01-0145-FEDER-000016 (NanoSTIMA) and NORTE-01-0145-FEDER-000026 (DeM), financed by the Regional Operational Program of the North (NORTE2020), under PORTUGAL2020 and FEDER